Patient w/ normal renal function CrCl >80 mL/min 250-750 mg orally every 24 hr. 250-500 mg by slow infusion over 60 min every 24 hr or 750 mg by slow infusion over 90 min every 24 hr.
Community acquired pneumonia 500 mg every 24 hr for 7-14 days or 750 mg every 24 hr for 5 days.
Nosocomial pneumonia 750 mg every 24 hr for 7-14 days.
Acute bacterial sinusitis 500 mg every 24 hr for 7-14 days or 750 mg every 24 hr for 5 days.
Acute bacterial exacerbation of chronic bronchitis 500 mg every 24 hr for 7 days or 750 mg every 24 hr for 3-5 days.
Chronic bacterial prostatitis 500 mg every 24 hr for 28 days.
Complicated SSSI, UTI & acute pyelonephritis 250-750 mg once daily for 7-14 days depending on the severity of the disease.
Patient w/ impaired renal function CrCl >50 mL/min 250 or 500 mg/24 hr,
CrCl 50-20 mL/min Initially 250 mg then 125 mg/24 hr or 500 mg then 250 mg/24 hr,
CrCl 19-10 mL/min Initially 250 mg then 125 mg/48 hr or 500 mg then 125 mg/24 hr,
CrCl <10 mL/min including hemodialysis & continuous ambulatory peritoneal dialysis Initially 250 mg then 125 mg/48 hr or 500 mg then 125 mg/24 hr.
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