Serious infections due to levofloxacin-sensitive microorganism eg, acute maxilliary sinusitis, acute exacerbation of chronic bronchitis, community-acquired pneumonia, complicated UTI, uncomplicated skin & soft tissue infections, acute pyelonephritis.
Dosage/Direction for Use
OralAdult Usual dose 250-750 mg once daily. Chronic bronchitis w/ acute exacerbation 500 mg/24 hr for 7 days. Community-acquired pneumonia 500 mg/24 hr for 7-14 days. Acute maxillary sinusitis 500 mg/24 hr for 10-14 days. Uncomplicated skin & skin structure infection 500 mg/24 hr for 7-10 days. Complicated UTI, acute pyelonephritis 250 mg/24 hr for 10 days. IV 500 mg/100 mL by slow IV infusion for not be <60 min or 750 mg/150 mL by slow IV infusion for 90 min.
Administration
May be taken with or without food: Ensure adequate fluid intake.
Discontinue treatment if shock or hypersensitivity reactions occur. Patients w/ sensitivity to neurological disorders. Blood glucose should be monitored in patients receiving oral hypoglycemic agents or insulin therapy. May affect ability to drive or operate machinery. Patients w/ impaired renal function. Elderly.
Absorption may be reduced by Al- & Mg-containing antacids, sucralfate, metal cations, multivit. NSAID may enhance CNS stimulation & convulsion. May increase theophylline conc in plasma. Antidiabetic including insulin.
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