Cromoglicic acid: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Inhalation/Respiratory
Asthma prophylaxis

Adult: 20 mg four times daily as dry powder/nebulised soln or 10 mg four times daily as aerosol, increased to 6-8 times daily if necessary, reduced to 5 mg four times daily once asthma has been stabilised. Additional doses may be taken before exercise.

Nasal
Allergic rhinitis

Adult: 2.5 or 5 mg of a 2% or 4% soln is admin as drops or spray into each nostril 4 times daily.

Ophthalmic
Allergic conjunctivitis

Adult: Instill 2 drops of a 4% soln 4-6 times daily or apply a 4% oint bid-tid.

Oral
Food allergy, Mastocytosis

Adult: 200 mg four times daily. May double the dose if effect is not satisfactory within 2-3 wk. Max: 40 mg/kg/day.
Child: 100 mg four times daily. May double the dose if effect is not satisfactory within 2-3 weeks.

Renal Impairment

Dosage adjustment may be needed.

Hepatic Impairment

Dosage adjustment may be needed.

Contraindications

Hypersensitivity.

Special Precautions

Lactation, cardiac arrhythmias, hepatic or renal dysfunction.

Adverse Reactions

Nausea, headache, dizziness, unpleasant taste, joint pain and swelling, skin rashes, aggravation of asthma, pulmonary infiltrates with eosinophilia, urticaria. Bronchospasm, wheezing, cough, nasal congestion and throat irritation following inhalation of dry powder. Intranasal use: Transient irritation of nasal mucosa. Sneezing and epistaxis (occasional). Eye drops: Transient burning and stinging.

Pregnancy Category (US FDA)

Ophth/PO: B

Action

Description:
Mechanism of Action: Cromoglycic acid inhibits degranulation of mast cells and therefore suppresses the release of histamine, leukotrienes and slow-reacting substance of anaphylaxis.
Pharmacokinetics:
Absorption: Oral: Poorly absorbed from the GIT with only 1% bioavailability. Inhalation: 8-10% of a dose of fine powd is deposited and rapidly absorbed from the lungs. Intranasal: < 7% of the dose is absorbed. Ophthalmic: 0.03% is absorbed.

Storage

Store at 25°C.

MIMS Class

Antihistamines & Antiallergics / Nasal Decongestants & Other Nasal Preparations / Ophthalmic Decongestants, Anesthetics, Anti-Inflammatories

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