Crotamiton: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Scabies

Adult: As 10% cream/lotion: Apply a thin layer uniformly and massage thoroughly onto the whole body from neck to toes after bathing and drying. Repeat application once daily, preferably in the evening, for a total of 3-5 days.
Child: <3 yr Apply once daily w/ medical supervision; ≥3 yr Same as adult dose.

Topical/Cutaneous
Pruritic skin disorders

Adult: As 10% cream/lotion: Apply gently onto affected area(s) bid or tid.
Child: <3 yr Apply once daily w/ medical supervision; ≥3 yr Same as adult dose.

Contraindications

Hypersensitivity. Acute exudative dermatoses.

Special Precautions

Childn. Pregnancy and lactation.

Adverse Reactions

Significant: Local hypersensitivity reaction and irritation.
Nervous: Localised warm feeling.
Dermatologic: Contact dermatitis, pruritus, rash.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid application to the face, eyes, mouth, or on acutely inflamed, denuded, or weeping skin.

Action

Description:
Mechanism of Action: Crotamiton is an acaricide agent that acts on the motor system of mites (e.g. Sarcoptes scabiei) through irreversible cessation of spontaneous movements. Additionally, it has antipruritic effects through inhibition of histamine, serotonin, and PAR-2.
Onset: Antipruritic effects: 6-10 hr.
Pharmacokinetics:
Absorption: Rapidly penetrates into the skin; systemically absorbed. Time to peak plasma concentration: 4-10 hr.
Excretion: Via urine (4.8-8.8%).

Chemical Structure

Storage

Store below 25°C.

MIMS Class

Topical Antifungals & Antiparasites

References

Anon. Crotamiton. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/07/2017.

Buckingham R (ed). Crotamiton. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/07/2017.

Eurax Cream; Lotion (Ranbaxy Laboratories Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/07/2017.

Joint Formulary Committee. Crotamiton. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/07/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Crotamiton (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 06/07/2017.

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