Cyclophosan Dosage & Drug Information

Concise Prescribing Info Bahasa Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Adverse Reactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cyclophosphamide monohydrate

Indications/Uses

Malignant tumours eg, pulmonary, mammary, ovarian carcinoma; malignant lymphogranulomatosis, lymphosarcoma, reticulum cell sarcoma, leukemias & multiple myeloma.

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Dosage/Direction for Use

IV Low dose: 80-240 mg/m² (2-6 mg/kg) wkly as a single dose or in divided doses orally. Medium dose: 400-600 mg/m² (10-15 mg/kg) wkly as a single dose. High dose: 800-1,600 mg/m² (20-40 mg/kg) as a single dose at 10-20 day intervals.

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Contraindications

Hypersensitivity & haemorrhagic cystitis. Bone marrow disorders. Pregnant or breastfeeding mothers.

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Special Precautions

Leukopenia; thrombocytopenia; tumour cell infiltration on bone marrow; previous x-ray therapy; previous therapy w/ other cytotoxic agents. Renal & hepatic impairment. May induce permanent sterility in childn.

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Adverse Reactions

Nausea & vomiting; hair loss; bone marrow depression (leukopenia, thrombocytopenia). Amenorrhea, azospermia & sterile haemorrhagic cystitis; alopecia; bladder fibrosis & carcinoma after long term use; liver dysfunction; hyperpigmentation; oral ulceration.

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Storage

View Cyclophosan storage conditions for details to ensure optimal shelf-life.

Description

View Cyclophosan description for details of the chemical structure and excipients (inactive components).

Action

View Cyclophosan mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Cytotoxic Chemotherapy

ATC Classification

L01AA01 - cyclophosphamide ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.

Regulatory Classification

Presentation/Packing

Form

Cyclophosan powd for inj (lyo) 200 mg

Packing/Price

1's (Rp180,000/boks)

Cyclophosan

cyclophosphamide

Manufacturer:

Sanbe

Marketer:

Sanbe