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Indications and Dosage
Oral
Hypertension Adult: 10-20 mg once-bid, increased by 10-20 mg every 3 or 4 days according to severity of condition. Maintenance: 20-120 mg daily.
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Contraindications
Phaeochromocytoma, heart failure.
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Special Precautions
Renal impairment, coronary or cerebral arteriosclerosis, asthma, history of peptic ulceration, pregnancy. Abrupt cessation may lead to rebound hypertension.
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Adverse Reactions
Postural hypotension, failure of ejaculation, fluid retention, nasal decongestion, headache, diarrhoea, drowsiness.
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Drug Interactions
Adrenaline, amfetamine, other sympathomimetics, TCAs, MAOIs, phenothiazine derivatives and related antipsychotics, oral contraceptives, digoxin or other digitalis derivatives, thiazide diuretics, other antihypertensives, levodopa, alcohol.
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Action
Description:
Mechanism of Action: Debrisoquine acts by selectively inhibiting transmission in postganglionic adrenergic nerves. It acts mainly by preventing the release of noradrenaline at nerve endings. It does not prevent the catecholamine secretion by the adrenal medulla. Onset: 4-10 hr. Duration: 9-24 hr. Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract. Metabolism: Main metabolite: 4-hydroxydebrisoquine. |
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MIMS Class
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