Delapril

Oral
Hypertension

Aortic stenosis or outflow tract obstruction, active or suspected renovascular disease. Pregnancy.

Patient w/ history of idiopathic or hereditary angioedema, diarrhoea, water or Na depletion, peripheral vascular disease or generalised atherosclerosis, collagen vascular disorders (e.g. SLE, scleroderma). Renal impairment. Lactation.

Hypotension, dizziness, fatigue, headache, GI disturbances, persistent dry cough and other upper resp tract symptoms, angioedema, blood disorders (e.g. neutropenia and agranulocytosis), hyperkalaemia, hyponatraemia, skin rashes.

Assessment of renal function prior and throughout therapy. Monitor serum K level, WBC count and presence of protein in urine regularly.

Additive hyperkalaemic effects w/ K-sparing diuretics, K supplements, other drugs that can cause hyperkalaemia (e.g. ciclosporin, indometacin).

Avoid alcohol as it may potentially result to excessive hypotension.

Description:
Mechanism of Action: Delapril inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased in plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention). It may also inhibit the degradation of bradykinin.

ACE Inhibitors/Direct Renin Inhibitors

Anon. Delapril. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 14/03/2014.

Buckingham R (ed). ACE Inhibitors. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/03/2014.

Buckingham R (ed). Delapril. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/03/2014.