Desonide: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Corticosteroid-responsive dermatoses

Adult: As 0.05% cream, oint, or lotion: Apply sparingly onto the affected areas 2-4 times daily until optimal response is achieved. Max duration of therapy: 8 wk.
Child: ≥ 2 yr Same as adult dose.

Topical/Cutaneous
Atopic dermatitis

Adult: As 0.05% foam or gel: Apply to affected area(s) bid. Max duration of therapy: 4 wk.
Child: ≥3 mth Same as adult dose.

Contraindications

Viral skin infections (e.g. vaccinia, herpes simplex), TB, acne and rosacea; ulcerated lesions.

Special Precautions

Childn. Pregnancy and lactation.

Adverse Reactions

Pruritus, pain, folliculitis, rash, peripheral oedema, pustular rash, sweating, erythema, irritation, burning, itching, dryness, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration/atrophy, secondary infection, striae and miliaria. Adrenal suppression, manifestations of Cushing syndrome, hyperglycaemia or glycosuria, facial swelling, withdrawal syndrome, growth retardation in childn (systemic).

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid use w/ occlusive dressing. Desonide foam is flammable, do not smoke during or immediately after application.

Monitoring Parameters

Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression thru ACTH stimulation test, plasma cortisol test and urinary free cortisol test; signs and symptoms of bacterial or fungal infection.

Drug Interactions

Enhanced effect w/ other topical corticosteroids.

Action

Description:
Mechanism of Action: Desonide is a synthetic corticosteroid that induces phospholipase A₂ inhibitory proteins (lipocortins) and sequentially inhibits release of arachidonic acid, hence depresses the formation, release, and activity of chemical inflammatory mediators.
Pharmacokinetics:
Absorption: Absorbed through normal skin; increased percutaneous absorption in traumatised or inflamed skin.
Metabolism: Metabolised in the liver.
Excretion: Mainly via urine; bile.

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Topical Corticosteroids

ATC Classification

D07AB08 - desonide ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.

References

Anon. Desonide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/10/2016.

Buckingham R (ed). Desonide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/10/2016.

Desonide Cream (G&W Laboratories, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/10/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Desonide (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 04/10/2016.

Verdeso Aerosol, Foam (Aqua Pharmaceuticals) . DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 11/10/2016.

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