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Indications and Dosage
Topical/Cutaneous
Corticosteroid-responsive dermatoses Adult: As 0.05-0.25% cream/gel/lotion/oint: Apply a thin film onto affected area bid. Rub in gently. Child: Same as adult dose. Topical/Cutaneous Plaque psoriasis Adult: As 0.25% spray: Apply a thin film onto affected area bid. Rub in gently.
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Special Precautions
Childn. Pregnancy and lactation.
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Adverse Reactions
Atrophy, striae, telangiectasias, burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentations, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, miliaria. Reversible HPA axis suppression, Cushing’s syndrome, hyperglycaemia, unmasking of latent DM (from systemic absorption).
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Topical: C
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Patient Counseling Information
Avoid use of occlusive dressings. Topical spray is flammable, avoid exposure to heat and flame or smoking during or immediately after application.
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Monitoring Parameters
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression through ACTH stimulation or urinary free cortisol test.
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Drug Interactions
May diminish the antineoplastic effect of aldesleukin. May potentiate the hyperglycaemic effect of ceritinib. May diminish the therapeutic effect of corticorelin and hyaluronidase. May enhance the adverse/toxic effects of deferasirox.
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Action
Description:
Mechanism of Action: Desoximetasone is a topical corticosteroid that induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid hence depresses the formation, release, and activity of endogenous chemical mediators such as kinins, histamine, liposomal enzymes, and prostaglandins. Pharmacokinetics: Absorption: Absorbed through normal skin; increased percutaneous absorption in traumatised or inflamed skin. Metabolism: Metabolised in the liver. Excretion: Via urine and faeces. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Desoximetasone, CID=5311067, https://pubchem.ncbi.nlm.nih.gov/compound/Desoximetasone (accessed on Jan. 20, 2020) |
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Storage
Store between 20-25°C. Spray: Protect from heat or flame.
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MIMS Class
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ATC Classification
D07AC03 - desoximetasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
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References
Anon. Desoximetasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 23/11/2016. Buckingham R (ed). Desoximetasone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 23/11/2016. Desoximetasone Cream (Perrigo New York Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016. Desoximetasone Ointment (Teligent Pharma, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016. McEvoy GK, Snow EK, Miller J et al (eds). Desoximetasone (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 23/11/2016. Topicort Ointment USP 0.05% (Taro Pharmaceuticals Inc) . U.S. FDA. https://www.fda.gov/. Accessed 23/11/2016. Topicort Spray (Taro Pharmaceuticals U.S.A., Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016.
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