Significant bladder outlet obstruction at risk for urinary retention, GI obstructive disorders eg, pyloric stenosis. Autonomic neuropathy, hiatus hernia, organic reason for urgency & frequency should be considered before treatment. Myasthenia gravis. Congenital or documented acquired QT prolongation. Patients who are taking class IA (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol) antiarrhythmic medications. Concomitant medication w/ potent CYP3A4 inhibitors, eg, macrolide antibiotics (erythromycin & clarithromycin) or antifungal agents (ketoconazole, itraconazole & miconazole). Renal or hepatic disease. May affect ability to drive or operate machinery. Women of fertile age should use adequate contraception. Pregnancy & lactation. Childn.
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