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Indications and Dosage
Parenteral
Susceptible infections Adult: 1-3 mg/kg daily by IM or slow IV infusion in divided doses. Adjust dose based on serum monitoring.
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Contraindications
Pregnancy; hypersensitivity; known or suspected perforation of the eardrum (topical application into the ear).
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Special Precautions
Myasthenia gravis; regular assessment of auditory and renal function is necessary in patients with additional risk factors. Monitoring is important in patients on high doses or prolonged courses, impaired renal function; infants, elderly, obese, cystic fibrosis.
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Adverse Reactions
Ototoxicity; nephrotoxicity; acute renal failure, decreased glomerular filtration rate; electrolyte disturbances; respiratory depression; muscular paralysis; hypersensitivity reactions; atrophy or fat necrosis at Inj sites; cross-sensitivity with other aminoglycosides.
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Drug Interactions
Other nephrotoxic drugs e.g. vancomycin, cephalosphorins, ciclosporin, cisplatin and fludarabine; potentially ototoxic drugs e.g. ethacrynic acid, furosemide; neuromuscular-blocking agents; general anaesthetics; opioids; β-lactams; dimenhydrinate.
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Action
Description:
Mechanism of Action: Dibekacin is an aminoglycoside derived from kanamycin. It binds to 30s and 50s subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against gram-negative aerobes and some strains of Staphylococci. |
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MIMS Class
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