Diiodohydroxyquinoline: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Bacterial skin infections, Skin fungal infections

Adult: Apply to affected area(s) 3-4 times daily.
Child: >12 years Same as adult dose.

Contraindications

Hypersensitivity.

Special Precautions

Patient with thyroid abnormalities. Children. Pregnancy and lactation. Prolonged use.

Adverse Reactions

Significant: Hypersensitivity reactions, overgrowth of nonsusceptible organisms (prolonged use).

Pregnancy Category (US FDA)

PO/Topical: C

Patient Counseling Information

Avoid contact with eyes. Avoid use with occlusive dressing. May cause discolouration of skin, hair and dyed fabrics.

Lab Interference

May interfere with thyroid function test. May give false-positive ferric chloride test for phenylketonuria.

Action

Description:
Mechanism of Action: Diiodohydroxyquinoline is a halogenated 8-hydroxyquinoline, an amoebicide with antifungal and antibacterial properties. It chelates trace metals at bacterial surfaces, which are essential for bacterial growth. Synonym: iodoquinol.
Pharmacokinetics:
Absorption: Absorbed systemically through the skin.

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Topical Antibiotics / Topical Antifungals & Antiparasites

ATC Classification

G01AC01 - diiodohydroxyquinoline ; Belongs to the class of quinolone derivative antiinfectives. Used in the treatment of gynecological infections.

References

Aloquin Gel (Primus Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 03/05/2018.

Anon. Iodoquinol (Topical). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 03/05/2018.

Anon. Iodoquinol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/05/2018.

Buckingham R (ed). Diiodohydroxyquinoline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/05/2018.

Quinja Gel (Novum Pharma, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 03/05/2018.

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