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Indications and Dosage
Oral
Allergic conditions Adult: As maleate: 1-2 mg tid. Topical/Cutaneous Pruritic skin disorders Adult: As 0.1% gel/lotion: Use as directed.
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Contraindications
Neonates, infants, urinary retention, paralytic ileus.
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Special Precautions
Elderly, closed-angle glaucoma, benign prostatic hyperplasia, driving, epilepsy, GI tract obstruction. Pregnancy and lactation.
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Adverse Reactions
CNS depression, paradoxical CNS excitation, dryness of mouth, thickened resp mucus, urinary retention, constipation, tachycardia and arrhythmias, blurring of vision, GI upsets, blood dyscrasias. Topical application: Sensitisation.
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Drug Interactions
Masks ototoxicity produced by aminoglycosides and antibiotics. Potentiate CNS depressant actions of alcohol, barbiturates, sedatives, opioid analgesics and neuroleptics. May block the effects of betahistine. QT prolongation may occur when used with mefloquine. May cause increased sedative effects when used with thalidomide.
Potentially Fatal: Additive antimuscarinic action with MAOIs, atropine and TCAs. |
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Action
Description:
Mechanism of Action: Dimethindene is an alkylamine derivative. It is mildy sedative and have mast-cell stabilising properties. It is also a potent H1-antagonist and possesses significant sedative actions. May cause paradoxical stimulation of CNS esp in children. |
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MIMS Class
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