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This drug is used in combination with levodopa-containing products. The usual adult dosage for oral use is 50 mg of safinamide once daily. The dosage for oral use may be administered at 100 mg once daily according to the patient’s condition.
Precautions concerning dosage and administration: 1. Coadministration with levodopa-containing products may cause adverse reactions of levodopa origin (dyskinesia, etc.). Therefore, patients should be closely monitored when the dosing of this drug is started or the dose of this drug is increased, and if such adverse reactions occur, the dose of this drug or levodopa-containing products should be adjusted.
2. The dose of Equfina should not exceed 50 mg daily for patients with moderate hepatic impairment (Child-Pugh B) (see Patients with Hepatic Impairment under Precautions and Pharmacology: Pharmacokinetics under Actions).
