Breast cancer, NSCLC, ovarian cancer, prostate cancer.
Dosage/Direction for Use
Breast cancer Monotherapy: 100 mg/m2. In combination w/ doxorubicin: Docetaxel 75 mg/m2 + doxorubin 59 mg/m2. In combination w/ capecitabine: Docetaxel 75 mg/m2 3 wkly + capecitabine 1,250 mg/m2 twice daily for 2 wk followed by a 1-wk rest period. NSCLCChemotherapy-naive patient Docetaxel 75 mg/m2 immediately followed by cisplatin 75 mg/m2 over 30-60 min. For treatment after failure of prior platinum-based therapy: 75 mg/m2 as a single agent. Prostate cancer Docetaxel 75 mg/m2 + prednisone or prednisolone 5 mg orally twice daily administered continuously.
Monitor CBC. Perform cardiac assessment before initiating docetaxel plus trastuzumab therapy. Monitor & treat symptoms of GI toxicity diarrhea w/ or w/o neutropenia.
Adverse Reactions
Neutropenia, hypersensitivity reactions, rash including localized eruptions mainly on the feet & hands, severe nail disorders, venous thromboembolic events, acute resp distress syndrome, interstitial pneumonia, pulmonary fibrosis, amenorrhea.
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