Adult & childn 8 yr >45 kg Initially 200 mg as a single dose or 100 mg twice daily followed by a maintenance dose of 100 mg daily as a single dose or 50 mg twice daily. More severe infections: 200 mg daily. Childn 8 yr <45 kg 4.4 mg/kg daily in 2 divided doses on the 1st day followed by 2.2 mg/kg on subsequent days. More severe infections: 2.2 mg/kg 12 hrly. Uncomplicated gonococcal, urethral, endocervical or rectal infections, non gonococcal urethritis 100 mg twice daily for 7 days. Primary & secondary syphilis 300 mg daily in divided doses for 10 days.
Liver diseases & concomitant use w/ hepatotoxic drugs. Perform hematopoietic, renal & hepatic function test in long-term use. Permanent discoloration of the teeth if used during pregnancy, lactation & in childn <8 yr.
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