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Susceptible Gram-negative infections, Susceptible Gram-positive infections, Susceptible infections
Adult: 200 mg on the 1st day given in 1 or 2 infusions, followed by 100-200 mg daily depending on the severity of the infection. Doses are given via infusion over 1-4 hours (depending on the dose).
Child: >8 years ≤45 kg: 4.4 mg/kg in 2 divided doses on the 1st day, followed by maintenance dose of 2.2 mg/kg daily (given as a single dose or in 2 divided doses); >45 kg: Same as adult dose. For severe infections: <45 kg: 2.2 mg/kg 12 hourly; ≥45 kg: Same as adult dose.
Child: >8 years ≤45 kg: 4.4 mg/kg in 2 divided doses on the 1st day, followed by maintenance dose of 2.2 mg/kg daily (given as a single dose or in 2 divided doses); >45 kg: Same as adult dose. For severe infections: <45 kg: 2.2 mg/kg 12 hourly; ≥45 kg: Same as adult dose.
Intravenous
Inhalational anthrax
Adult: Postexposure treatment: 100 mg bid via infusion over 1-4 hours. Substitute oral therapy as soon as possible and continue for a total of 60 days.
Child: Postexposure treatment: <45 kg: 2.2 mg/kg bid via infusion over 1-4 hours. Substitute oral therapy as soon as possible and continue for a total of 60 days.
Child: Postexposure treatment: <45 kg: 2.2 mg/kg bid via infusion over 1-4 hours. Substitute oral therapy as soon as possible and continue for a total of 60 days.
Oral
Primary syphilis, Secondary syphilis
Adult: As conventional cap, conventional or delayed-release tab, or oral susp: As an alternative therapy in non-pregnant penicillin-allergic patients: 100 mg or 200 mg bid for 2 weeks. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Susceptible Gram-negative infections, Susceptible Gram-positive infections, Susceptible infections
Adult: As conventional cap, conventional or delayed-release tab, or oral susp: Usual dose: 200 mg on the 1st day (given as a single dose or in 2 divided doses at 12-hour interval), followed by a maintenance dose of 100 mg daily. For more severe infections: 200 mg daily given throughout treatment. For streptococcal infections, continue treatment for 10 days. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Child: As conventional cap, conventional or delayed-release tab, or oral susp: Acute infections: 8-<12 years ≤45 kg: 4.4 mg/kg on the 1st day (given as a single dose or in 2 divided doses), followed by maintenance dose of 2.2 mg/kg daily (given as a single dose or in 2 divided doses); >45 kg: Same as adult dose. 12-<18 years Same as adult dose. For more severe infections: 8-<12 years ≤45 kg: Up to 4.4 mg/kg given throughout treatment; >45 kg: Same as adult dose. 12-<18 years Same as adult dose. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Child: As conventional cap, conventional or delayed-release tab, or oral susp: Acute infections: 8-<12 years ≤45 kg: 4.4 mg/kg on the 1st day (given as a single dose or in 2 divided doses), followed by maintenance dose of 2.2 mg/kg daily (given as a single dose or in 2 divided doses); >45 kg: Same as adult dose. 12-<18 years Same as adult dose. For more severe infections: 8-<12 years ≤45 kg: Up to 4.4 mg/kg given throughout treatment; >45 kg: Same as adult dose. 12-<18 years Same as adult dose. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Epididymo-orchitis
Adult: For the treatment of acute cases caused by Chlamydia trachomatis or Neisseria gonorrhoeae: As conventional cap, conventional or delayed-release tab, or oral susp: 100 mg bid for 10 days. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Chloroquine-resistant falciparum malaria
Adult: As conventional cap or tab: In combination with a rapid-acting schizonticide (e.g. quinine): 200 mg daily for at least 7 days. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Louse-borne relapsing fever, Tick-borne relapsing fever
Adult: As conventional cap or tab: 100 mg or 200 mg as a single dose according to severity. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Uncomplicated endocervical infections caused by Chlamydia trachomatis, Uncomplicated gonorrhoea, Uncomplicated rectal infections caused by Chlamydia trachomatis, Uncomplicated urethral infections caused by Chlamydia trachomatis
Adult: As conventional cap, conventional or delayed-release tab, or oral susp: 100 mg bid for 7 days. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Prophylaxis of scrub typhus
Adult: As conventional cap or tab: 200 mg as a single dose. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Inhalational anthrax
Adult: Postexposure prophylaxis: As conventional cap, conventional or delayed-release tab, or oral susp: 100 mg bid for 60 days. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Child: Postexposure prophylaxis: As conventional cap, conventional or delayed-release tab, or oral susp: <45 kg: 2.2 mg/kg bid for 60 days; ≥45 kg: Same as adult dose.
Child: Postexposure prophylaxis: As conventional cap, conventional or delayed-release tab, or oral susp: <45 kg: 2.2 mg/kg bid for 60 days; ≥45 kg: Same as adult dose.
Oral
Leptospirosis
Adult: For prophylaxis: As conventional cap or tab: 200 mg once weekly throughout the stay in the area for up to 21 days and 200 mg at the completion of the trip. For treatment: As conventional tab: 100 mg bid for 7 days. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Prophylaxis of traveller's diarrhoea
Adult: As conventional cap or tab: 200 mg on the 1st day of travel (given as a single dose or as 100 mg 12 hourly), followed by 100 mg daily throughout the stay in the area. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Prophylaxis of malaria
Adult: As conventional cap, conventional or delayed-release tab, or oral susp: 100 mg daily beginning 1-2 days before travel to the malarious area, continued daily during travel and for 4 weeks after leaving the area. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Child: As conventional cap, conventional or delayed-release tab, or oral susp: >8 years 2 mg/kg once daily up to the adult dose, beginning 1-2 days before travel to malarious area, continued daily during travel and for 4 weeks after leaving the area. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Child: As conventional cap, conventional or delayed-release tab, or oral susp: >8 years 2 mg/kg once daily up to the adult dose, beginning 1-2 days before travel to malarious area, continued daily during travel and for 4 weeks after leaving the area. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Rosacea
Adult: To reduce papulopustular lesions: As 40 mg modified-release cap: 40 mg once daily in the morning, preferably at least 1 hour before or 2 hours after meals. Evaluate after 6 weeks; consider discontinuing treatment if no effect is seen. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Nongonococcal urethritis
Adult: For the treatment of cases caused by Ureaplasma urealyticum or Chlamydia trachomatis: As conventional cap, conventional or delayed-release tab, or oral susp: 100 mg bid for 7 days. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Acne vulgaris
Adult: As conventional cap or tab: 50-100 mg daily for 6-12 weeks. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Oral
Periodontitis
Adult: As adjunct to supragingival and subgingival scaling and root planing: As 20 mg conventional tab: 20 mg bid for 3-9 months. Doses to be taken at least 1 hour before or 2 hours after meals.
Oral
Rocky Mountain spotted fever
Adult: As conventional cap, conventional or delayed-release tab, or oral susp: 100 mg 12 hourly. Continue for at least 3 days after the fever subsides and until there is evidence of clinical improvement. Minimum duration: 5-7 days. Dosage recommendations and indications may vary among countries or individual products. Refer to specific product guidelines.
Child: As conventional cap, conventional or delayed-release tab, or oral susp: <45 kg: 2.2 mg/kg bid; ≥45 kg: Same as adult dose. Continue for at least 3 days after the fever subsides and until there is evidence of clinical improvement. Minimum duration: 5-7 days.
Child: As conventional cap, conventional or delayed-release tab, or oral susp: <45 kg: 2.2 mg/kg bid; ≥45 kg: Same as adult dose. Continue for at least 3 days after the fever subsides and until there is evidence of clinical improvement. Minimum duration: 5-7 days.
