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Indications and Dosage
Oral
Antispasmodic Adult: 40-80 mg tid.
Child: 1-6 yr: 20 mg 3-4 times daiily; >6 yr: 40 mg tid. |
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Administration
May be taken with or without food.
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Contraindications
Severe renal/hepatic/cardiac dysfunction. Porphyria.
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Special Precautions
Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.
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Adverse Reactions
Vertigo, nausea, vomiting, dry mouth.
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Drug Interactions
May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.
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Action
Description:
Mechanism of Action: Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain. |
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MIMS Class
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