Not approved for prevention of prostate cancer. May increase risk of high-grade prostate cancer. Risk of heart failure. May cause breast enlargement & tenderness. Additional check-up may be needed for patients w/ liver problems. Patients w/ severe kidney problems. Stop treatment before cataract surgery. Affects blood test for PSA. Regularly perform PSA blood test. May affect ability to drive or operate machinery. Reduced male fertility w/ dutasteride. Dutasteride is absorbed through the skin; may affect normal development of a male baby. Presence of dutasteride in semen; avoid exposing pregnant partner to the semen. Women, childn & adolescents must not handle leaking cap.
Do not take w/ other α-blockers. Not recommended w/ ketoconazole. Possible side effects w/ PDE5 inhibitors eg, vardenafil, sildenafil citrate & tadalafil; verapamil or diltiazem; ritonavir or indinavir; itraconazole or ketoconazole; nefazodone; cimetidine; warfarin; erythromycin; paroxetine; terbinafine; diclofenac.
G04CA52 - tamsulosin and dutasteride ; Belongs to the class of alpha-adrenoreceptor antagonists. Used in the treatment of benign prostatic hypertrophy.
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