Econazole: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Nail fungal infections

Adult: As 1% cream or lotion: Apply once daily under occlusive dressing. For tinea pedis: As 1% cream or foam: Apply once daily for 4 wk.
Child: ≥12 yr For tinea pedis: As 1% foam: Apply once daily for 4 wk.

Topical/Cutaneous
Tinea corporis, Tinea cruris, Tinea versicolor

Adult: As 1% cream: Apply once daily for 2 wk.

Topical/Cutaneous
Cutaneous candidiasis

Adult: As 1% cream: Apply bid (morning and evening) for 2 wk.

Vaginal
Vaginal candidiasis

Adult: As pessary: Insert 150 mg pessary intravaginally at bedtime for 3 consecutive nights, or as single dose in long-acting preparations.

Contraindications

Hypersensitivity.

Special Precautions

Patient using spermicidal contraceptives. Pregnancy and lactation.

Adverse Reactions

Burning and stinging sensation, pruritus, erythema, rash; contact dermatitis.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

May damage latex contraceptive diaphragms and condoms, avoid use during treatment. Avoid contact w/ eyes, nose, mouth or other mucous membranes. Avoid heat, flame and smoking upon application of foam preparation.

Drug Interactions

May enhance anticoagulant effect of warfarin or acenocoumarol.

Action

Description:
Mechanism of Action: Econazole modifies the permeability of cell wall membrane in fungi; may interfere w/ RNA and protein synthesis, and lipid metabolism.
Pharmacokinetics:
Absorption: Insignificant (topical or vaginal).

Chemical Structure

Storage

Store between 15-30°C.

MIMS Class

Preparations for Vaginal Conditions / Topical Antifungals & Antiparasites

References

Anon. Econazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 22/07/2014.

Buckingham R (ed). Econazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/07/2014.

Econazole Nitrate Cream (Prasco Laboratories). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/07/2014.

Ecoza Aerosol, Foam (Quinnova Pharmaceuticals, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Econazole Nitrate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 22/07/2014.

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