Efalizumab: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Subcutaneous
Psoriasis

Adult: Initially, 0.7 mg/kg; followed by a wkly dose of 1 mg/kg. Treatment period is usually 12 wk, to continue only when there is improvement. Max: 200 mg/dose.

Contraindications

Known hypersensitivity. Should not be used in patients with clinically important infections.

Special Precautions

Monitor platelet counts before and during treatment. Acellular, live and live-attenuated vaccines should not be given during treatment. Pregnancy and lactation.

Adverse Reactions

Headache, fever, nausea, vomiting.

Drug Interactions

Avoid concurrent admin of other immunosuppressive agents or with phototherapy.

Action

Description:
Mechanism of Action: Efalizumab is a recombinant humanized anti-CD11a monoclonal antibody functioning as an immunosuppressive agent used in the management of moderate to severe chronic plaque psoriasis.
Pharmacokinetics:
Absorption: Plasma concentrations peak 1-2 days after SC inj; bioavailability: About 50%.
Metabolism: Metabolised by intracellular degradation.
Excretion: Time to elimination after the last dose is about 25 days.

MIMS Class

Immunosuppressants

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