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Indications and Dosage
Oral
Allergic conditions Adult: 25-50 mg daily.
Elderly: Child: Same as adult dose. |
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Contraindications
Urinary or GI tract obstruction, paralytic ileus. Pregnancy and lactation.
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Special Precautions
Patient w/ closed-angle glaucoma, prostate enlargement, heart disease, and epilepsy. Childn.
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Adverse Reactions
Headache, sleep disorder, hypotension, loss of appetite, asthma, bone marrow depression, constipation, drowsiness, increased sweating, tingling, shock, swelling, wt gain, urinary hesitancy, urinary retention, CNS depression, dry mouth, thickening of resp secretions, blurred vision, GI upset, tinnitus, vertigo, giddiness, nausea, paraesthesia, bradycardia followed by tachycardia and arrhythmias; paradoxical stimulation in childn.
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Patient Counseling Information
May impair ability to drive or operate machinery.
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Drug Interactions
Additive anti-muscarinic effect w/ MAOIs, TCAs and atropine. Enhances the CNS depressant effect of barbiturates, sedatives, hypnotics, analgesics and neuroleptics. Masks ototoxicity produced by aminoglycosides.
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Food Interaction
Enhances the CNS depressant effect of alcohol.
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Action
Description:
Mechanism of Action: Embramine selectively binds to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. |
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Storage
Store at room temp.
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MIMS Class
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References
Buckingham R (ed). Embramine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/04/2016. Embramine. National Center for Biotechnology Information. PubChem Database. https://pubchem.ncbi.nlm.nih.gov/. Accessed 15/04/2016 . Mebryl (GlaxoSmithKline). MIMS India. http://www.mims.com/india. Accessed 15/04/2016 .
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