Emedastine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Ophthalmic
Seasonal allergic conjunctivitis

Adult: As 0.05% emedastine difumarate soln: Instill 1 drop to the affected eye(s) up to 4 times daily.
Child: ≥3 yr Same as adult dose.

Special Precautions

Lactation. Not indicated for contact lens-related irritation.

Adverse Reactions

Significant: Corneal infiltrates.
Nervous: Headache, asthenia, abnormal dreams.
GI: Dysgeusia.
Ophthalmologic: Blurred vision, ocular burning, stinging, discomfort, dryness, pruritus, and hyperemia; corneal staining, foreign body sensation, keratitis, lacrimation.
Resp: Rhinitis, sinusitis.
Dermatologic: Dermatitis.

Pregnancy Category (US FDA)

Ophth: B

Patient Counseling Information

This drug may cause blurred vision or other visual disturbances, if affected, do not drive or operate machinery.

Action

Description:
Mechanism of Action: Emedastine is a selective histamine (H₁) receptor antagonist for ophthalmic use.
Pharmacokinetics:
Absorption: Minimally absorbed.
Excretion: Elimination half-life: 10 hr.

Chemical Structure

Storage

Store between 4-30°C.

MIMS Class

Ophthalmic Decongestants, Anesthetics, Anti-Inflammatories

ATC Classification

S01GX06 - emedastine ; Belongs to the class of other ophthalmologic antiallergics.

References

Anon. Emedastine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/03/2017.

Buckingham R (ed). Emedastine Fumarate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/03/2017.

Emadine Solution/Drops (Alcon Laboratories, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 02/03/2017.

Joint Formulary Committee. Emedastine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/03/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Emedastine Difumarate (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 02/03/2017.

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