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Indications and Dosage
Oral
Urinary tract infections Adult: 200-400 mg bid. Oral Uncomplicated gonorrhoea Adult: 400 mg as a single dose.
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Administration
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals w/ full glass of water. Ensure adequate fluid intake daily. Avoid caffeine.
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Contraindications
Hypersensitivity; lactation; child; adolescent; pregnancy.
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Special Precautions
Impaired hepatic or renal function; G6PD deficiency; myasthenia gravis; maintain adequate fluid intake; avoid excessive alkalinity of the urine, exposure to strong sunlight/sunlamp; epilepsy; history of CNS disorders. Discontinue in case of tendon pain, inflammation or rupture. May impair ability to drive and operate machinery. High level of resistance with Staph. aureus infections.
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Adverse Reactions
GI disturbances; CNS effects; hypersensitivity-type reactions; reversible arthralgia; hepatic effects; haematological disturbances; tachycardia; superinfection; pain and irritation at Inj site; tendon damage; phlebitis and thrombophloebitis.
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Drug Interactions
May inhibit hepatic metabolism and clearance of drugs metabolized in the liver eg theophylline and caffeine; antacids and metal cations; antineoplastics.
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Lab Interference
Elevated liver enzyme values.
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Action
Description:
Mechanism of Action: Enoxacin inhibits DNA gyrase and topoisomerase IV which are essential in bacterial DNA reproduction. |
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MIMS Class
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