Epalrestat: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Diabetic neuropathy

Adult: 50 mg tid.

Action

Description:
Mechanism of Action: Epalrestat inhibits aldose reductase enzyme which catalyses the conversion of glucose to sorbitol. Accumulation of sorbitol in certain cells occurs only in conditions of hyperglycaemia and resulting in hyperosmotic effect which may be involved in pathogenesis of some diabetic complications. Aldose reducatse inhibitors have no effect on blood-glucose concentrations.

MIMS Class

Antidiabetic Agents

References

Buckingham R (ed). Epalrestat. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/09/2014.

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