Epinastine

Ophthalmic
Allergic conjunctivitis

Pregnancy and lactation.

Nervous: Headache.
GI: Taste disturbance.
Resp: Upper resp infection, cough, rhinitis, sinusitis, pharyngitis.
Ophthalmologic: Burning sensation, folliculosis, conjunctival hyperaemia, dryness, pain, pruritus, increased lacrimation, visual disturbance.

Ophth: C

Remove contact lenses prior to instillation and may be reinserted after 10-15 min.

Description:
Mechanism of Action: Epinastine, a selective H₁-receptor antagonist, inhibits the release of histamine from mast cells. It also possesses affinity to H₂, α₁, α ₂, and 5-HT₂  receptors.
Onset: 3-5 min.
Duration: 8 hr.
Pharmacokinetics:
Absorption: Minimal systemic absorption after topical application. Time to peak plasma concentration: Approx 2 hr.
Distribution: Volume of distribution: 417 L. Plasma protein binding: 64%.
Metabolism: >10% is metabolised.
Excretion: Via urine (as unchanged drug). Terminal elimination half-life: 12 hr.

Source: National Center for Biotechnology Information. PubChem Database. Epinastine, CID=3241, https://pubchem.ncbi.nlm.nih.gov/compound/Epinastine (accessed on Jan. 22, 2020)

Store between 20-25°C.

Ophthalmic Decongestants, Anesthetics, Anti-Inflammatories

S01GX10 - epinastine ; Belongs to the class of other ophthalmologic antiallergics.

Anon. Epinastine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 28/02/2017.

Buckingham R (ed). Epinastine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/02/2017.

Epinastine Hydrochloride Solution (Apotex Corp.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 28/02/2017.

Joint Formulary Committee. Epinastine Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/02/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Epinastine Hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 28/02/2017.