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Increase yield of autologous blood
Adult: 600 units/kg 2 times a wk starting 3 wk before surgery. May be used in conjunction with an iron supplement.
Parenteral
Anaemia in zidovudine-treated HIV-infected patients
Adult: Titrate dose for patients individually so as to achieve and maintain the lowest haemoglobin level sufficient to avoid the need for blood transfusion and not to exceed 12 g/dL. For patients with serum erythropoietin levels ≤500 mUnits/mL who are receiving zidovudine dose ≤4200 mg/wk: Starting dose: 100 units/kg via SC/IV Inj 3 times a wk for 8 wk, may increase by 50-100 units/kg 3 times a wk at 4-8 wk intervals according to response. Not recommended to administer doses >300 units/kg 3 times a wk.
Parenteral
Anaemia of chronic renal failure
Adult: In predialysis and haemodialysis: Initially, 50 IU/kg 3 times weekly via IV Inj over at least 1-5 minutes or as slow IV Inj in patients who have flu-like symptoms as adverse effect. May also be given via SC inj. Doses may be increased in increments of 25 units/kg at 4-week intervals until the target is reached. In peritoneal dialysis: Initially, 50 units/kg SC twice weekly. Weekly maintenance dose: Predialysis: Total max: 450 units/kg in 3 divided doses. Alternatively, max 20,000 units via SC injection given once weekly or once every 2 weeks. Haemodialysis: 75-300 units/kg in 3 divided doses. Peritoneal dialysis: 50-100 units/kg in 2 divided doses.
Child: Haemodialysis: Initially, 50 units/kg 3 times weekly, given via IV inj. May increase dose by increments of 25 units/kg at 4-week intervals until the target Hb concentration is reached (9.5-11 g/mL). Total weekly maintenance dose: Haemodialysis: >30 kg: 90-300 units/kg; 10-30 kg: 180-450 units/kg; <10 kg: 225-450 units/kg. To be given in 3 divided doses.doses.
Child: Haemodialysis: Initially, 50 units/kg 3 times weekly, given via IV inj. May increase dose by increments of 25 units/kg at 4-week intervals until the target Hb concentration is reached (9.5-11 g/mL). Total weekly maintenance dose: Haemodialysis: >30 kg: 90-300 units/kg; 10-30 kg: 180-450 units/kg; <10 kg: 225-450 units/kg. To be given in 3 divided doses.doses.
Subcutaneous
Anaemia related to non-myeloid malignant disease chemotherapy
Adult: Initially, 150 units/kg 3 times weekly or 450 units/kg once weekly, increased after 4-8 weeks to 300 units/kg 3 times weekly, if necessary. Alternatively, 40,000 units once weekly, may increase to 60,000 once weekly units after 4 weeks if necessary. Stop treatment if response is still inadequate after 4 weeks of treatment at this higher dose.
Subcutaneous
Reduce the need for allogeneic blood transfusion
Adult: 600 units/kg once wkly starting 3 wk before surgery with the 4th dose given on the day of the surgery or 300 units/kg daily starting 10 days before surgery and for 4 days after.
