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Pulmonary hypertension
Adult: Initially, given at a rate of 2 ng/kg/minute, then increase by increments of 2 ng/kg/minute at intervals of at least 15 minutes until max haemodynamic benefits/dose-limiting effects occur. Then, may be given at a rate of 4 ng/kg/minute less than the max tolerated infusion rate. If the max rate is <5 ng/kg/minute, then initial rate should be 1/2 of the max rate. Adjust maintenance dose according to response. If symptoms recur or if adverse effects occur, increase or decrease dose in steps of 1-2 ng/kg/minute at intervals of at least 15 minutes until a new maintenance dose is established.
Child: Neonates Initially, 2 ng/kg/min given via IV infusion, adjust according to response up to max 20 ng/kg/min. 1 month to 17 years Initially, 2 ng/kg/min given via IV infusion, increase to 40 ng/kg/min, if necessary. Prolonged treatment may lead to tolerance to epoprostenol and doses up to 120 ng/kg/min may be required.
Child: Neonates Initially, 2 ng/kg/min given via IV infusion, adjust according to response up to max 20 ng/kg/min. 1 month to 17 years Initially, 2 ng/kg/min given via IV infusion, increase to 40 ng/kg/min, if necessary. Prolonged treatment may lead to tolerance to epoprostenol and doses up to 120 ng/kg/min may be required.
Intravenous
Prophylaxis of platelet aggregation
Adult: Usual dose for renal dialysis: 4 ng/kg/min via IV inj before dialysis, then 4 ng/kg/min into the arterial inlet of the dialyser during dialysis.
