Erenumab: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Subcutaneous
Prophylaxis of migraine

Adult: In patients who have at least 4 migraine days per month: 70 mg once every 4 weeks, may increase to 140 mg every 4 weeks if necessary. Consider discontinuing treatment if there is no response after 3 months.

Special Precautions

Patient with CV or cerebrovascular diseases. Pregnancy and lactation.

Adverse Reactions

Significant: Constipation, hypersensitivity reactions (e.g. rash, angioedema, anaphylaxis).
Injury, poisoning and procedural complications: Injection site reactions (e.g. pain, erythema).
Musculoskeletal and connective tissue disorders: Muscle cramps or spasm.

Monitoring Parameters

Monitor the number of monthly migraine days and the treatment benefit within 3 months after initiation.

Action

Description:
Mechanism of Action: Erenumab is a recombinant human monoclonal antibody which binds to and inhibits the activity of calcitonin gene-related peptide (CGRP), a peptide involved in the pathophysiology of migraine.
Pharmacokinetics:
Absorption: Bioavailability: 82%. Time to peak plasma concentration: Approx 6 days.
Distribution: Crosses placenta.
Metabolism: Metabolised via nonspecific, nonsaturable proteolytic pathways.
Excretion: Elimination half-life: 28 days.

Storage

Store between 2-8°C. Do not freeze or shake. Protect from light.

MIMS Class

Antimigraine Preparations

ATC Classification

N02CD01 - erenumab ; Belongs to the class of calcitonin gene-related peptide (CGRP) antagonists preparations. Used to relieve migraine.

References

Aimovig Injection, Solution (Amgen Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/04/2020.

Anon. Erenumab. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 07/04/2020.

Anon. Erenumab. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/04/2020.

Buckingham R (ed). Erenumab. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/04/2020.

Joint Formulary Committee. Erenumab. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/04/2020.

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