Erythromycin + Zinc acetate: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Acne vulgaris

Adult: As soln: Apply bid to the affected area for 10-12 wk.
Elderly: Same as adult dose.
Child: Same as adult dose.

Contraindications

Hypersensitivity to erythromycin, zinc acetate, or other macrolide antibiotics.

Adverse Reactions

Rarely, hypersensitivity, pruritus, dry skin, erythema; skin irritation, burning sensation and exfoliation.

Patient Counseling Information

Avoid contact w/ eyes or mucous membranes of the nose and mouth.

Overdosage

Symptoms: Idiosyncratic hypersensitivity. Management: Wash the treated area w/ copious water and simple soap.

Drug Interactions

May occur cross resistance w/ other macrolide group antibiotics, and w/ lincomycin and clindamycin.

Action

Description:
Mechanism of Action: Erythromycin exerts its antibacterial activity by inhibiting RNA-dependent protein synthesis at the chain elongation step. It binds to 50S ribosomal subunit which blocks transpeptidation. Zinc induces copper binding protein metallothionein production in enterocytes. Copper binding w/in enterocytes may impair intestinal absorption of dietary copper and reabsorption of endogenously secreted copper in saliva, bile, gastric acid.
Onset: Zinc: Slow.
Pharmacokinetics:
Absorption: Penetrates independently.

Storage

Store below 25°C.

MIMS Class

Acne Treatment Preparations

ATC Classification

D10AF52 - erythromycin, combinations ; Belongs to the class of topical antiinfective preparations used in the treatment of acne.

References

Anon. Erythromycin (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/03/2016.

Anon. Zinc acetate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/03/2016.

Joint Formulary Committee. Erythromycin with Zinc acetate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/03/2016.

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