Significant unintentional wt loss, recurrent vomiting, dysphagia, hematemesis or melena; gastric ulcer. Exclude malignancy. Risk of GI infections eg, Salmonella & Campylobacter. Co-administration w/ clopidogrel, omeprazole & atazanavir. If co-administration w/ atazanir is unavoidable, closely monitor doses of atazanavir up to 400 mg w/ 100 mg of ritonavir, esomeprazole should not exceed 20 mg. CYP2C19 metabolized drugs. Pregnancy & lactation.