Estriol

Oral
Menopausal hormone replacement therapy

Oral
Infertility due to cervical hostility

Vaginal
Menopausal atrophic vaginitis

May be taken with or without food.

Pregnancy, thrombosis, known or suspected oestrogen-dependent tumors, vag bleeding, history of undiagnosed manifesation of deterioration of otosclerosis during pregnancy or previous use of steroids.

Thrombosis, severe liver disorders, porphyria, history during pregnancy or previous use of steroids of severe pruritus, cholestatic jaundice, herpes gestationis or otosclerosis. Lactation.

Breast tension or pain, nausea, spotting. Fluid retention, cervical hypersecretion.

Reduced efficacy may occur when used with activated charcoal, barbiturates, carbamazepine, griseofulvin, hydantoin and rifampicin. May possibly change efficacy of oral anticoagulants and increase pharmacologic effects of succinylcholine, theophyllines and troleandromycin.

Reduce responses to metyrapone test. May interfere with thyroid function and glucose tolerance tests.

Description:
Mechanism of Action: Estriol is a naturally occurring oestrogen. It induces normalization of vag epithelium. It is claimed to have only a mild proliferative effect on the endometrium. It only has a short retention time in the nuclei of endometrial cells.

Oestrogens, Progesterones & Related Synthetic Drugs / Preparations for Vaginal Conditions