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Chronic moderate to severe plaque psoriasis
Adult: Initially, 25 mg twice wkly or 50 mg once wkly. Alternatively, 50 mg twice wkly at intervals of 3-4 days for up to 12 wk, then reduce to 25 mg twice wkly or 50 mg once wkly. Continue treatment until remission is achieved, up to 24 wk. Discontinue if no response after 12 wk.
Child: Chronic severe plaque psoriasis: ≥6 yr 0.8 mg/kg once wkly for up to 24 wk. Max: 50 mg wkly. Discontinue if no response after 12 wk.
Child: Chronic severe plaque psoriasis: ≥6 yr 0.8 mg/kg once wkly for up to 24 wk. Max: 50 mg wkly. Discontinue if no response after 12 wk.
Subcutaneous
Juvenile idiopathic arthritis
Child: ≥2 yr 0.4 mg/kg (max: 25 mg) twice wkly at intervals of 3-4 days, or alternatively, 0.8 mg/kg (max: 50 mg) once wkly. Discontinue treatment if no response after 6 mth or initial response is not maintained.
Subcutaneous
Ankylosing spondylitis, Rheumatoid arthritis
Adult: 25 mg twice wkly at intervals of 3-4 days or 50 mg once wkly. Discontinue treatment if no response after 6 mth for rheumatoid arthritis, and after 12 wk for ankylosing spondylitis.
Subcutaneous
Psoriatic arthritis
Adult: 25 mg twice wkly at intervals of 3-4 days or 50 mg once wkly. Discontinue treatment if no response after 12 wk.
Child: ≥12 yr 0.4 mg/kg (max: 25 mg) twice wkly at intervals of 3-4 days, or alternatively, 0.8 mg/kg (max: 50 mg) once wkly. Discontinue treatment if no response after 6 mth or initial response is not maintained.
Child: ≥12 yr 0.4 mg/kg (max: 25 mg) twice wkly at intervals of 3-4 days, or alternatively, 0.8 mg/kg (max: 50 mg) once wkly. Discontinue treatment if no response after 6 mth or initial response is not maintained.
