Adult Max: 6.5 mg/kg daily based on ideal body wt 1-2 times daily. Patient who received >400 mg Initial dose: 400 mg in divided doses. Decrease dose into 200 mg if there is no significant changes. Maintenance dose may be increased to 400 mg if needed. Childn >31 kg Do not exceed 6.5 mg/kg daily based on ideal body wt.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to 4-aminoquinolone compd. Eye maculopathy. Childn <6 yr (<31 kg).
Special Precautions
Eye exam related to the risk of retinopathy before & after treatment. Low visual acuity. Hypoglycemia. Pregnancy & lactation. Elderly.
May increase serum levels of digoxin. Reduction of insulin dose or antidiabetic drugs may be needed. May prolong QT interval & increase risk of ventricular arrhythmias w/ drugs that have the potential to induce cardiac arrhythmias eg, metfloquine. Antiepileptic drug activity may be disrupted. May increase side effects w/ MTX. Increased levels of cyclosporine.
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