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Indications and Dosage
Oral
Respiratory tract infections, Uncomplicated skin and skin structure infections Adult: As faropenem medoxomil: 300 mg bid for 7-10 days.
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Contraindications
History of hypersensitivity to faropenem and other penems, anaphylactic reaction to β-lactams.
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Adverse Reactions
Diarrhoea, nausea, vomiting and abdominal pain.
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Food Interaction
Slightly delays time to peak plasma concentration w/ food.
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Action
Description:
Mechanism of Action: Faropenem is a penem antimicrobial and has bactericidal activity against a variety of gm-ve, gm+ve and anaerobic bacteria. Pharmacokinetics: Absorption: Food slightly delays time to peak plasma concentration. Time to peak plasma concentration: W/in 1-2 hr. Distribution: Plasma protein binding: 89-90%. Metabolism: Metabolised by renal dihydropeptidase I to 2 inactive metabolites. Excretion: Half-life: Approx 1 hr. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Faropenem, CID=65894, https://pubchem.ncbi.nlm.nih.gov/compound/Faropenem (accessed on Jan. 20, 2020) |
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MIMS Class
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References
Buckingham R (ed). Faropenem Sodium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 22/09/2014. Wickersham RM. Faropenem Medoxomil. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 22/09/2014.
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