IM Adult Abdominal distention Initially 5 U, may increase to 10 U at subsequent inj; given at 3 or 4 hr interval. Abdominal roentgenography 2 inj of 10 U, given 2 hr & 1½ hr respectively. Diabetes insipidus 5-10 U 2-3 times daily; may be given by inj or intranasally on cotton pledgets, by nasal spray or by dropper. IV Infusion Emergency management of acute GI bleeding Initially, 0.2-0.6 U/min, may increased to ≥0.6 U/min 30-60 min interval. After bleeding is controlled, continue effective dose 12-24 hr, dose should then be gradually tapered over the next 24-48 hr.
Presence of epilepsy, migraine, asthma, heart failure, renal failure. Do not use in patients w/ vascular disease, especially disease of the coronary arteries. Small doses may precipitate anginal pain & the possibility of MI w/ larger doses. May produce water intoxication. Recognize the early signs of drowsiness, listlessness & headaches to prevent terminal coma & convulsions. Care should be taken to avoid extravascular tissue infiltration at the infusion site. May cause intense vasoconstriction that may lead to local necrosis & sloughing. Monitor ECG & fluid & electrolyte status. Conventional supportive measures (eg, blood transfusion, esophageal tamponade, paracentesis, nasogastric lavage) should accompany the use of vasopressin. Pregnancy & lactation.
May potentiate the antidiuretic effect w/ carbamazepine, chlorpropamide, clofibrate, urea, fludrocortisone, TCA. May decrease the antidiuretic effect w/ demeclocycline, norepinephrine, lithium, heparin, alcohol. May produced a marked increase in sensitivity to the pressor effects w/ ganglionic blocking agents.
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