Local reactions: Exacerbation of infections, skin atrophy especially on face & skin fold; leading to skin thinning, depigmentation, vasodilatation, acne, papillary dermatitis. Systemic reactions: Suppression of hypophyseal axis. Osteoporosis, moonface, buffalo hump, hirsutism (long-term therapy). Adrenal suppression & hypercorticism in prolonged & extensive use in childn.