RA, OA (arthrosis, degenerative joint disease), ankylosing spondylitis 20 mg as a single daily dose. A relatively small group of patients may be maintained on 10 mg daily. Some patients may require up to 30 mg daily given in single or divided doses. Acute gout Initially single dose of 40 mg, followed by another 40 mg on the next 4-6 days in single or divided doses. Acute musculoskeletal disorders Initially 40 mg daily for 1st 2 days in single or divided doses. For the remainder of 7-14 day treatment period, reduce dose to 20 mg daily.
Should be taken with food: Place on the tongue to disperse, then swallow.
Contraindications
Hypersensitivity. History of GI ulceration, bleeding or perforation. Active peptic ulceration or history of recurrent ulceration. Cross-sensitivity to ASA or NSAIDs. Treatment of peri-op pain in the setting of CABG surgery. Severe heart failure. Severe renal & hepatic failure.
Not for long-term management of gout. History of GI disease. W/draw if PUD, perforation or GI bleeding occurs. CHF, liver cirrhosis, nephrotic syndrome, overt renal disease. Interstitial nephritis, glomerulitis, papillary necrosis. Ophth evaluation for patients w/ visual complaints. Phenylketonuria. Pregnancy & lactation. Childn.
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