Fenbufen: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Pain and inflammation associated with musculoskeletal and joint disorders

Adult: 900 mg daily, given either as 450 mg in the morning and evening or 300 mg in the morning and 600 mg in the evening.

Administration

Should be taken with food. Take w/ or immediately after meals.

Contraindications

Hypersensitivity to fenbufen or other NSAIDs. Lactation.

Special Precautions

Patient w/ gastric ulcer, cardiac disorders. Renal or hepatic impairment. Pregnancy.

Adverse Reactions

Nervous: Depression, dizziness, headache, numbness.
GI: Anorexia, vomiting, abdominal pain, heartburn, diarrhoea, black stool, constipation, dry/sore mouth.
Resp: Wheezing, dyspnoea.
Ophthalmologic: Visual disturbance.
Otic: Tinnitus.
Dermatologic: Rash, toxic epidermal necrolysis, oedema, photosensitivity.
Others: Fatigue.
Potentially Fatal: Erythema multiforme, Stevens-Johnson syndrome.

Patient Counseling Information

This drug may cause blurred vision, if affected, do not drive or operate machinery.

Drug Interactions

Decreased serum concentration w/ aspirin. Risk of convulsions when given w/ quinolones (e.g. enoxacin, ofloxacin). May enhance the anticoagulant effect of coumarins.

Action

Description:
Mechanism of Action: Fenbufen is a propionic acid derivative which prevents the synthesis of prostaglandins by inhibiting cyclooxygenase.
Pharmacokinetics:
Absorption: Absorbed from the GI tract. Time to peak plasma concentration: Approx 70 min.
Distribution: Enters breast milk (small amounts). Plasma protein binding: >99%.
Metabolism: Metabolised in the liver to active metabolites, biphenylacetic acid and 4-hydroxy-biphenylbutyric acid.
Excretion: Via urine (mainly as conjugates). Plasma half-life: Approx 10-17 hr.

Chemical Structure

Storage

Store below 25°C.

MIMS Class

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

ATC Classification

M01AE05 - fenbufen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.

References

Anon. Fenbufen. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/02/2017 .

Buckingham R (ed). Fenbufen. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/02/2017 .

Preston CL (ed). Fenbufen Interactions. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/02/2017 .

Disclaimer: This information is independently developed by MIMS based on Fenbufen from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com