Inhalation/Respiratory Prophylaxis of exercise-induced asthma, Reversible airways obstruction
Adult: As metered-dose inhaler (100 mcg/dose): 1-2 inhalations as needed. Max: 8 inhalations daily. As soln (50 mcg/drop): 0.5 mL (10 drops or 500 mcg) up to 4 times daily.
Inhalation/Respiratory Acute asthma
Adult: As metered-dose inhaler (100 mcg/dose): 1 inhalation as needed, if symptoms are not adequately controlled after 5 min, a 2nd dose may be given. As soln (50 mcg/drop): 0.5 mL (10 drops or 500 mcg), may require higher doses between 1-1.25 mL (20-25 drops or 1,000-1,250 mcg) in severe cases. Child: 6-12 yr 22-36 kg/body wt: As soln (50 mcg/drop): 0.25-0.5 mL (5-10 drops or 250-500 mcg). May require higher doses up to 1 mL (20 drops or 1,000 mcg) in severe cases.
Patient w/ severe asthma, underlying severe heart disease (e.g. ischaemic heart disease, severe organic heart disease, arrhythmia, severe heart failure), insufficiently controlled DM, recent MI, hyperthyroidism, phaeochromocytoma, and severe vascular disorder. Pregnancy and lactation.
Symptoms: Palpitation, tachycardia, tremor, HTN, hypotension, widening of pulse pressure, anginal pain, arrhythmias, flushing, metabolic acidosis. Management: Admin of tranquilisers, sedatives in severe cases; β-receptor blockers preferably β1-selective. Intensive therapy may be required.
Drug Interactions
Increased effect w/ β-adrenergics, anticholinergics, MAOIs, TCAs and xanthine derivatives (e.g. theophylline). Serious reduction in bronchodilation w/ β-blockers. May enhance susceptibility to CV effects w/ halothane, enflurane, and trichloroethylene.
Action
Description: Mechanism of Action: Fenoterol is a direct-acting sympathomimetic agent w/ predominant β-adrenoceptor stimulant activity largely selective for β2-receptors. Onset: W/in a few min (inhalation). Duration: Approx 3-5 hr (inhalation). Pharmacokinetics: Absorption: Incompletely absorbed from the GI tract. Distribution: Enters breast milk. Metabolism: Undergoes extensive first-pass metabolism via sulfate conjugation Excretion: Via urine and bile (mainly as inactive sulfate conjugate).
Chemical Structure
Fenoterol Source: National Center for Biotechnology Information. PubChem Database. Fenoterol, CID=3343, https://pubchem.ncbi.nlm.nih.gov/compound/Fenoterol (accessed on Jan. 20, 2020)
R03CC04 - fenoterol ; Belongs to the class of adrenergics for systemic use, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases. R03AC04 - fenoterol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
References
Anon. Fenoterol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/02/2016 .Berotec. MIMS Indonesia. http://mims.com/indonesia. Accessed 10/02/2016 .Buckingham R (ed). Fenoterol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/02/2016 .
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