Flavoxate: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Bladder spasms due to catheterisation, Dysuria, Urinary incontinence, urgency and frequency

Adult: 100-200 mg 3-4 times daily. May reduce when symptoms improve.
Child: ≥12 yr Same as adult dose.

Administration

May be taken with or without food.

Contraindications

Pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, achalasia, GI haemorrhage, and obstructive uropathies of the lower urinary tract.

Special Precautions

Patient w/ suspected glaucoma (esp closed angle glaucoma); serious, uncontrolled, obstructive disorders of the lower urinary tract. Childn. Pregnancy and lactation.

Adverse Reactions

Nervous: Drowsiness, headache, vertigo, nervousness, mental confusion.
CV: Palpitation, tachycardia.
GI: Nausea, vomiting, dry mouth/throat, abdominal pain, constipation.
Resp: Reduced bronchial secretions.
Genitourinary: Dysuria.
Haematologic: Leucopenia, eosinophilia.
Ophthalmologic: Increased intraocular tension, accommodation disturbance, blurred vision, photophobia.
Dermatologic: Dryness, flushing, urticaria and other dermatoses.
Others: Hyperpyrexia.

Pregnancy Category (US FDA)

PO: B

Patient Counseling Information

This drug may cause drowsiness and blurred vision, if affected, do not drive or operate machinery.

Drug Interactions

Increased CNS effects w/ other sedative agents.

Food Interaction

Increased CNS effects w/ alcohol.

Action

Description:
Mechanism of Action: Flavoxate is a tertiary amine w/ direct relaxant effect on smooth muscles through inhibition of phosphodiesterase, thereby reducing symptoms associated w/ bladder spasticity. It also has antimuscarinic effects.
Onset: 55 min.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: Approx 2 hr.
Metabolism: Rapidly metabolised, mainly to the active metabolite methyl flavone carboxylic acid (MFCA).
Excretion: Via urine (approx 50-60%, as MFCA).

Chemical Structure

Storage

Store between 20-25°C. Protect from light.

MIMS Class

Drugs for Bladder & Prostate Disorders

ATC Classification

G04BD02 - flavoxate ; Belongs to the class of urinary antispasmodics.

References

Anon. Flavoxate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/03/2017.

Buckingham R (ed). Flavoxate Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/03/2017.

Flavoxate Hydrochloride Tablet (Epic Pharma, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/03/2017.

Joint Formulary Committee. Flavoxate Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/03/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Flavoxate Hydrochloride. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 06/03/2017.

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