Flubendazole: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Enterobiasis

Adult: 100 mg as a single dose. Repeat after 2-3 wk as required.
Child: Same as adult dose.

Oral
Ascariasis, Hookworm infections, Trichuriasis

Adult: 100 mg bid for 3 days.
Child: Same as adult dose.

Contraindications

Pregnancy.

Special Precautions

Lactation. Monitor blood counts and liver function tests regularly during treatment.

Adverse Reactions

GI disturbances; headache, dizziness; allergic reactions; raised liver enzyme values; alopoecia; bone marrow suppression.

Drug Interactions

Enzyme inducers eg phenytoin or carbamazepine; and inhibitors eg cimetidine.

Action

Description:
Mechanism of Action: Flubendazole inhibits cytoplasmic microtubules in the intestinal or absorptive cells of the worms, thus inhibiting glucose uptake and glycogen storage depletion, leading to death of the worms within days.

MIMS Class

Anthelmintics

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