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Indications and Dosage
Topical/Cutaneous
Pain and inflammation associated with musculoskeletal and joint disorders Adult: Apply as a topical preparation at 3% or 3.5%.
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Contraindications
Hypersensitivity to aspirin or any other NSAIDs. Porphyria, active peptic ulceration.
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Special Precautions
History of peptic ulceration. May mask signs of infection eg, fever. Patients with haemorrhagic disorders, hypertension, and impaired renal, hepatic, or cardiac function. Monitor for blood, kidney, liver, or eye disorders. Reduce dose in elderly.
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Adverse Reactions
Photosensitivity, acute protocolitis, gastrointestinal discomfort, nausea, and diarrhoea
Potentially Fatal: Hypersensitivity and asthma. |
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Drug Interactions
May enhance the effects of oral anticoagulants, phenytoin and sulphonylureas. May increase plasma concentrations of lithium, methotrexate, and cardiac glycosides. Increased risk of hyperkalaemia with ACE inhibitors and potassium-sparing diuretics. May reduce antihypertensive action of some antihypertensives such as ACE inhibitors. May increase the risk of convulsions with quinolones.
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Lab Interference
May lower serum-thyroid hormone levels.
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Action
Description:
Mechanism of Action: Flufenamic acid is an NSAID which is an anthranilic acid derivative of mefenamic acid. |
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