Adult: As 0.05% cream/gel/solution/ointment: Apply thinly onto affected area(s) 2-4 times daily depending on the severity of the condition. Reduce dosage once the condition improves. As 0.1% cream: Apply thinly onto affected area(s) once or twice daily. Discontinue when control is achieved; re-evaluate treatment if condition does not improve within 2 weeks. Child: As 0.05% cream/gel/solution/ointment: >1 year Use the minimum effective dose and limit treatment to 5 days without occlusion. As 0.1% cream: ≥12 years Same as adult dose.
Monitor HPA axis suppression (e.g. ACTH stimulation test, urine free cortisol test); signs of bacterial or fungal infection. Routinely check growth in children (prolonged use).
Drug Interactions
May diminish the antineoplastic effect of aldesleukin.
Action
Description: Mechanism of Action: Fluocinonide is a highly potent fluorinated corticosteroid which has anti-inflammatory, antipruritic, and vasoconstrictive effects. It depresses the formation, release, and action of endogenous chemical mediators of inflammation (e.g. kinins, histamine, liposomal enzymes, prostaglandins) via the induction of phospholipase A2 inhibitory proteins (lipocortins) and sequential inhibition of arachidonic acid release. Pharmacokinetics: Absorption: Absorbed percutaneously. Metabolism: Metabolised mainly in the liver. Excretion: Via urine and bile.
Chemical Structure
Fluocinonide Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 9642, Fluocinonide. https://pubchem.ncbi.nlm.nih.gov/compound/Fluocinonide. Accessed Oct. 27, 2020.
Storage
Store between 15-30°C. Protect from excessive heat exposure.
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