Fluorescein


Generic Medicine Info
Indications and Dosage
Intravenous
Angioscopy of the retinal and iris vasculature
Adult: 500 mg (as 500 mg/5 mL solution) as a single dose via rapid inj into the antecubital vein at a rate of 1 mL per second.  For highly sensitive imaging system, reduce dose to 200 mg.
Child: 7.7 mg/kg as a single dose into antecubital vein. Max: 500 mg.

Ophthalmic
Aid in the fitting of hard contact lenses, Detection of corneal lesions and foreign bodies, Diagnostic ophthalmic procedures
Adult: As 1% or 2% solution: Instill dropwise onto the affected eye(s). As a sterile strip impregnated with 0.6 or 1 mg fluorescein sodium: Apply tip to conjunctiva or formix until adequately stained.

Oral
Assessment of exocrine pancreatic function
Adult: 348.5 mg fluorescein dilaurate (equivalent to 0.5 mmol of fluorescein), given with meal. Collect urine for the next 10 hour. A control dose of 188.14 mg fluorescein Na (equivalent to 0.5 mmol of fluorescein) is given the following day under the same conditions.
Contraindications
Acute necrotising pancreatitis (oral fluorescein dilaurate).
Adverse Reactions
Nausea and vomiting (IV); extravasation is painful; hypersensitivity reactions; transient yellow coloration of skin and urine; staining of the skin, clothing and soft contact lenses.
Potentially Fatal: Cardiac arrest and fatalities.
IV/Ophth/Parenteral: C
Action
Description:
Mechanism of Action: Fluorescein, a precursor of the eosins, temporarily stains any cell it enters therefore marking any damaged areas.
MIMS Class
Radiographic & Diagnostic Agents
Disclaimer: This information is independently developed by MIMS based on Fluorescein from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com
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