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Indications and Dosage
Intramuscular
Psychoses Adult: Initially, 2 mg wkly via deep IM inj. May nncrease according to patient's response. Maintainence: 1-10 mg wkly.
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Contraindications
Comatose states, CNS depression, phaeochromocytoma.
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Special Precautions
Hepatic impairment, renal impairment, CV disease, Parkinson's disease, epilepsy, depression, myasthenia gravis, prostatic hypertrophy, severe resp disease, blood dyscrasias and history of jaundice. Elderly. Pregnancy and lactation. Antipsychotics may precipitate coma due to their hepatotoxicity. Photosensitisation may occur in higher doses. May impair ability to drive and operate machines.
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Adverse Reactions
Parkinsonian symptoms, dystonia, akathisia, tardive dyskinesia. Interference with temp regulation. Neuroleptic malignant syndrome. CNS effects, GI disturbances, nasal congestion, antimuscarinic symptoms, CV symptoms, ECG changes, endocrine effects, blood dyscrasias, photosensitisation, contact sensitisation and rashes, jaundice, corneal and lens opacities, purplish pigmentation of the skin, cornea, conjunctiva and retina.
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Drug Interactions
ACE inhibitors, α-blockers, amantadine, general anaesthetics, angiotensin-II receptor antagonists, antiarrhythmics, tricyclic antidepressants, anxiolytics and hypnotics, apomorphine, artemether with lumefantrine, barbiturates, bromocriptine, cabergoline, calcium-channel blockers, carbamazepine, cimetidine, ethosuximide, levodopa, lisuride, memantine, methyldopa, metoclopramide, opioid analgesics, oxcarbazepine, pergolide, phenytoin, pramipexole, primidone, ritonavir, ropinirole, sibutramine, sympathomimetics, terfenadine, tetrabenazine, tramadol and valproate. Alcohol.
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Action
Description:
Mechanism of Action: Fluspirilene is a diphenylbutylpiperidine antipsychotic and has general properties similar to those of the phenothiazine, chlorpromazine. It is used in the treament of schizophrenia. |
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MIMS Class
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