Imiquimod

Adult: For the treatment of clinically typical, nonhyperkeratotic, nonhypertrophic, visible or palpable cases: As 2.5% or 3.75% cream: Apply thinly onto the entire face or balding scalp once daily before bedtime for 2 weeks; after a 2-week treatment-free interval, repeat a 2nd 2-week treatment course. Assess response 8 weeks after the 2nd course. Max: 2 sachets daily or 2 full pump actuations daily. Rest periods may be taken if local skin reactions occur, but treatment period must not be extended due to missed doses or rest periods. Therapy must be continued for the full treatment course even if all actinic keratoses appear to be gone. As 5% cream: Apply onto the face or scalp 3 times each week before bedtime for 4 weeks; after a 4-week treatment-free interval, assess response then repeat another 4-week treatment course if any lesions persist. Alternatively, apply onto the face or scalp 2 times each week for 16 weeks. Max: 1 sachet at each application. Rest periods may be taken if local skin reactions occur, but the treatment period must not be extended beyond 4 weeks or 16 weeks due to missed doses or rest periods. All doses must be left on the skin for approx 8 hours, then washed with mild soap and water. Dosage and treatment recommendations may vary among individual products or between countries (refer to specific product or local guidelines).

Adult: For the treatment of biopsy-confirmed cases with a max tumour diameter of 2 cm located on the neck, trunk (except anogenital skin), or extremities (except hands and feet) when surgical methods are less appropriate and patient follow-up can be assured: As 5% cream: Apply sufficient amount to cover the lesion and 1 cm beyond it 5 times each week (on consecutive days) before bedtime; leave on skin for approx 8 hours, then wash with mild soap and water. Treatment duration: 6 weeks. Assess response 12 weeks after treatment completion.

Adult: As 3.75% cream: Apply thinly onto the affected area(s) once daily before bedtime; leave on the skin for approx 8 hours, then wash with mild soap and water. Continue treatment until total clearance or for a Max duration of 8 weeks. As 5% cream: Apply thinly 3 times each week (on alternate days) before bedtime; leave on the skin for 6-10 hours, then wash with mild soap and water. Continue treatment until total clearance or for a Max duration of 16 weeks. Dosage and treatment recommendations may vary among individual products or between countries (refer to specific product or local guidelines).