Metforlip/Metforlip SR Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Metformin HCl

Indications/Uses

NIDDM or type 2 diabetes as an adjunct to diet & exercise to improve glycemic control. May be used concomitantly w/ sulfonylurea or insulin to improve glycemic control in adults. Metforlip IDDM as adjuvant therapy in combination w/ insulin. Metforlip SR IDDM as adjuvant therapy in combination w/ insulin in patients who are often obese.

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Dosage/Direction for Use

Metforlip Adult & childn Initially 500 mg bd. Increase dose by increment of 500 mg wkly up to total of 2,000 mg daily, given in divided doses (bd-tds). Adults can be titrated from 500 mg bd to 850 mg bd after 2 wk. Metforlip SR Adult Initially 500 mg once daily. Increase dose by increment of 500 mg wkly up to max of 2,000 mg once daily. Consider 1,000 mg bd if glycemic control is not achieved.

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Administration

Should be taken with food.

Contraindications

Hypersensitivity. Diabetic coma & ketoacidosis. CHF, recent MI, trauma, dehydration, alcohol dependence. Renal impairment & chronic renal diseases. Pregnancy & lactation.

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Special Precautions

Not to be used in patients w/ serum creatinine levels above ULN. Regularly monitor renal function. Stop therapy 2-3 days prior to surgery & clinical investigations (eg, IV urology, angiography). Perform annual estimation of vit B₁₂ levels in patients on continuous therapy. Monitor blood glucose in concomitant use w/ sulfonylurea. Not recommended in childn. Elderly.

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Adverse Reactions

Minor GI disturbances, metallic taste & lactic acidosis may occur. Malabsorption of vit B₁₂& folic acid may be induced.

Drug Interactions

Reduced renal clearance w/ cimetidine. Antihyperglycemic & hyperlactataemic effect are potentiated w/ alcohol. May enhance effects of anticoagulants. Enhanced absorption w/ nifedipine.

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Storage

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Description

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Action

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MIMS Class

Antidiabetic Agents

ATC Classification

A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.

Regulatory Classification

POM

Presentation/Packing

Form

Metforlip SR ER tab 500 mg

Packing/Price

10 × 5's

Form

Metforlip FC tab 500 mg

Packing/Price

5 × 10's

Metforlip/Metforlip SR

metformin

Manufacturer:

Healthcare Pharma

Distributor:

San Lwin Trading

Marketer:

San Lwin Trading