Đa khoa | Medical News

Tricyclic antidepressant for IBS worth a try

Jairia Dela Cruz, 20240115140000

The tricyclic antidepressant amitriptyline, when used at low dose in the second-line treatment setting and titrated according to symptom response and side-effects, is safe and provides relief from symptoms of irritable bowel syndrome (IBS), as shown in the phase III ATLANTIS* trial.

Allopurinol reduces cirrhosis-related complications

Stephen Padilla, 20240115120000

Use of allopurinol 300 mg helps prevent the incidence of overall complications associated with liver cirrhosis, reports a study.

Can SLN mapping replace lymphadenectomy for surgical staging of early-stage EEC?

Audrey Abella, 20240115100000

Researchers from the KK Women’s and Children’s Hospital, Singapore found that sentinel lymph node (SLN) mapping is an acceptable and safe alternative to routine lymphadenectomy in the surgical staging of early-stage endometrioid endometrial cancer (EEC).

Antivirals underutilized after curative resection of HBV- or HCV-related HCC

Christina Lau, 20240115091119

Antiviral therapy is associated with substantial improvements long-term survival overall (OS) but severely underutilized after curative hepatic resection in patients with hepatitis B virus (HBV)– or hepatitis C virus (HCV)–related hepatocellular carcinoma (HCC), a real-world study involving predominantly Asian patients has shown.

Quitting benzos carries unexpected risks for long-term users

Jairia Dela Cruz, 20240114140000

Stopping prescription benzodiazepine treatment may leave long-term users worse off, with a study finding increases in the risks of death and other unfavourable events.

Resection plus chemo improves survival in patients with UCR-MAC-LM

Stephen Padilla, 20240114120000

Primary tumour resection (PTR) in combination with chemotherapy (C) appears beneficial to a specific subgroup of patients with unresectable colorectal mucinous adenocarcinoma with liver metastasis (UCR-MAC-LM) compared with PTR or C alone, suggests a study.

Voice-based AI makes insulin management a breeze for T2D patients

Jairia Dela Cruz, 20240113140000

A voice-based conversational artificial intelligence application helps type 2 diabetes (T2D) patients navigate basal insulin titration at home and, in turn, achieve rapid glycaemic control, as reported in a study.

Maintenance olaparib rechallenge improves PFS in ovarian cancer patients

Stephen Padilla, 20240113120000

Restarting treatment with maintenance olaparib in ovarian cancer patients who had received one prior poly(ADP-ribose) polymerase (PARP) inhibitor and at least two lines of platinum-based chemotherapy results in a modest but significant improvement in progression-free survival (PFS) compared with placebo, results of a phase III study have shown.

Dr Yasutoshi Kuboki, ESMO Asia 2023, CodeBreak 300

CodeBreaK 300: Sotorasib + panitumumab prolongs PFS in metastatic colorectal cancer

Elaine Soliven, 20240113000000

Adding sotorasib to panitumumab significantly improves progression-free survival (PFS) in patients with chemorefractory KRAS G12C-mutated metastatic colorectal cancer (mCRC) compared with investigator’s choice of standard of care treatment, according to the CodeBreaK 300 trial presented at ESMO Asia 2023.

Sacituzumab govitecan confers survival benefit in Asian patients with mBC

Elaine Soliven, 20240112150000

Sacituzumab govitecan improved progression-free survival (PFS) and overall survival (OS) in Asian patients with HR+/HER2– metastatic breast cancer (mBC) compared with the treatment of physician’s choice (TPC*), according to the EVER-132-002 study presented at ESMO Asia 2023.