Multidisciplinary | Medical News

Maintenance olaparib rechallenge improves PFS in ovarian cancer patients

Stephen Padilla, 20240113120000

Restarting treatment with maintenance olaparib in ovarian cancer patients who had received one prior poly(ADP-ribose) polymerase (PARP) inhibitor and at least two lines of platinum-based chemotherapy results in a modest but significant improvement in progression-free survival (PFS) compared with placebo, results of a phase III study have shown.

Survivors cope with life after testicular cancer

20240113110000

Testicular cancer survivors (TCSs) demonstrate similar health-related quality of life (HRQoL) to that of the general population at a median of 28 years since treatment initiation, reports a study.

Add-on clarithromycin boosts recovery from pneumonia

20240113060000

Adding clarithromycin to standard of care appears to improve clinical response and reduce inflammation in patients with community-acquired pneumonia, as reported in the phase III ACCESS trial.

Dr Yasutoshi Kuboki, ESMO Asia 2023, CodeBreak 300

CodeBreaK 300: Sotorasib + panitumumab prolongs PFS in metastatic colorectal cancer

Elaine Soliven, 20240113000000

Adding sotorasib to panitumumab significantly improves progression-free survival (PFS) in patients with chemorefractory KRAS G12C-mutated metastatic colorectal cancer (mCRC) compared with investigator’s choice of standard of care treatment, according to the CodeBreaK 300 trial presented at ESMO Asia 2023.

Tiotropium beneficial to patients with mild COPD

20240112180000

Treatment with tiotropium appears to reduce the risk of clinically important deterioration (CID) in patients with mild-to-moderate chronic obstructive pulmonary disease (COPD), including those with fewer respiratory symptoms, according to a study.

Sacituzumab govitecan confers survival benefit in Asian patients with mBC

Elaine Soliven, 20240112150000

Sacituzumab govitecan improved progression-free survival (PFS) and overall survival (OS) in Asian patients with HR+/HER2– metastatic breast cancer (mBC) compared with the treatment of physician’s choice (TPC*), according to the EVER-132-002 study presented at ESMO Asia 2023.

Regular hearing aid use can add years to life

Jairia Dela Cruz, 20240112140000

Among people with hearing loss, those who use their hearing aids regularly appear to live longer than those who do not use the device, according to a study.

$Patients with autoimmune hepatitis at higher risk of osteoporotic fracture$

Patients with autoimmune hepatitis at higher risk of osteoporotic fracture

20240112130000

The risk of osteoporotic fracture seems greater in patients with autoimmune hepatitis (AIH), reveals a recent study. In addition, those with cirrhosis and long-term use of glucocorticoids appear to be at much greater risk.

Semaglutide trims down weight in patients with severe obesity

Stephen Padilla, 20240112120000

Use of semaglutide 2.4 mg results in substantial weight reduction in patients with severe obesity who had previously undergone bariatric surgery (BS) but failed to achieve satisfactory weight loss, reports a recent study.

Long-term use of GH therapy safe in decompensated cirrhosis

20240112110000

It is safe to use long-term growth hormone (GH) therapy in patients with decompensated cirrhosis (DC), suggests a study, noting improvements in malnutrition and even quality of life (QoL). However, 12-month survival does not seem to improve.